Abstract
The objective of the present study was to evaluate the in vivo wound healing effect of water extract of Stereospernum kunthianum -bark. The plant is mainly used by the local people of Mayo-Danay, Cameron as wound healing agent. The healing activity was evaluatedin rats using excision and incision wound on normal dexamethasone-delayed wound healing. Control animals received normal saline topically while other groups received dexamethasone (i.m), water extract orally or dexamethasone with the plant extract. The extract treated wounds were found to epithelize faster than those of controls dexamethasone-treated rats. Significant increase in skin tensile strength was observed in earlier than in later groups. Histological examination of incision wounds of extract-treated group showed dense collagen cross-linking and numerous blood vessels. The present study concludes that the stem bark of Stereospernum kunthianum possesses excellent wound healing potential that may substantiate its use in the traditional medicine.
Highlights
The epidermis, the dermis of the skin normally exists in steady state equilibrium to form a protective barrier of internal organs against entry of infectious or other noxious agents from the environment
Tsala, et al.: Wound healing effect of S. kunthianum alkaloids, flavonoids, glycosides, proteins, reduced sugars, catechic tannins were identified while saponins gallate tannins were not detected in the extract.The extract was tested to contain 515 mg rutin equivalent/mg extract
DX significantly prolonged the epithelialization time to 31 days as compared with the control group.When given alone, the extract stimulated wound contraction in rats from day 2 post-wounding.The same extract significantly reduced the epithelialization period to 12-day, to about 18 days in DX treated rats.The epithelialization time of all groups is reported in Table 1 where the wound healing effect of the extract is clearly demonstrated
Summary
The epidermis, the dermis of the skin normally exists in steady state equilibrium to form a protective barrier of internal organs against entry of infectious or other noxious agents from the environment. Any damage to the skin layers initiates a complex biochemical response that leads to tissue repair or wound healing. This process is characterized by dynamic, interactive events described in three phases: Inflammation, proliferation remodeling (Singer and Clark, 1999). Wound healing is a result in any loss of continuity in the skin or any body tissue, following trauma, infection, or pathological process (Martin, 2013). Due to simplicity in the measurement of wound healing responses, the excision and incision skin-wound healing models in rodents are by far the most convenient reliable methods of study for potential new therapeutic agents. Medicinal plants have generated much interest in recent studies for treating skin ailments, as they
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