Abstract
Background Myocardial stiffness (MS) is elevated in heart failure with preserved ejection fraction(HFPEF)[1]. In addition, stiffness elevation in HFPEF exhibits directional dependency [2]. Conventional determinants of MS such as pressurevolume relationship and mechanical testing are invasive and hence clinically inefficient. Therefore, there is a need to non-invasively estimate anisotropic MS to assist in diagnosis and prognosis of HFPEF. In this study we implement waveguide cardiac magnetic resonance elastography (CMRE)[3] to demonstrate the feasibility of estimating anisotropic MS non-invasively in an in-vivo porcine model.
Highlights
Myocardial stiffness (MS) is elevated in heart failure with preserved ejection fraction(HFPEF)[1]
cardiac magnetic resonance elastography (CMRE) and DTI was performed at the same resolution and the parameters were FOV=320mm3; imaging matrix 128x128; slice thickness=2.5mm; DTI was registered with CMRE to exactly match the voxel information from both sets of acquisition
We have observed that compressional stiffness is higher than shear stiffness
Summary
Myocardial stiffness (MS) is elevated in heart failure with preserved ejection fraction(HFPEF)[1]. Stiffness elevation in HFPEF exhibits directional dependency [2]. Conventional determinants of MS such as pressurevolume relationship and mechanical testing are invasive and clinically inefficient. There is a need to non-invasively estimate anisotropic MS to assist in diagnosis and prognosis of HFPEF. In this study we implement waveguide cardiac magnetic resonance elastography (CMRE)[3] to demonstrate the feasibility of estimating anisotropic MS non-invasively in an in-vivo porcine model
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
