Abstract
Background Heart failure with preserved ejection fraction accounts for approximately half of all heart failure cases and is associated with similar morbidity and mortality. Although abnormalities of diastolic function are felt to play an important role, no specific treatments have been identified for this common condition, primarily because of poor understanding of its pathophysiology. Despite development of several murine models of this disease, accurate non-invasive assessment of diastolic function has been challenging. Echocardiographic measurements have been limited by small heart sizes, rapid ventricular rates and high inter-observer variability. The aim of this study was to assess the ability of ultra-high field, high temporal resolution CMR tagging to assess diastolic function in mice, compared to the gold-standard technique of invasive pressure-volume loop analysis.
Highlights
Heart failure with preserved ejection fraction accounts for approximately half of all heart failure cases and is associated with similar morbidity and mortality
The aim of this study was to assess the ability of ultra-high field, high temporal resolution CMR tagging to assess diastolic function in mice, compared to the gold-standard technique of invasive pressure-volume loop analysis
Myocardial tagged images were obtained at the mid-ventricular short axis from endsystole to end-diastole using a spatial modulation of magnetization (SPAMM) sequence (Figure 1A and B)
Summary
Heart failure with preserved ejection fraction accounts for approximately half of all heart failure cases and is associated with similar morbidity and mortality. Abnormalities of diastolic function are felt to play an important role, no specific treatments have been identified for this common condition, primarily because of poor understanding of its pathophysiology. Despite development of several murine models of this disease, accurate non-invasive assessment of diastolic function has been challenging. Echocardiographic measurements have been limited by small heart sizes, rapid ventricular rates and high inter-observer variability. The aim of this study was to assess the ability of ultra-high field, high temporal resolution CMR tagging to assess diastolic function in mice, compared to the gold-standard technique of invasive pressure-volume loop analysis
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