Abstract
CD4+CD25+ regulatory T-cells (Treg) have the potential to suppress aberrant immune responses and to regulate peripheral T-cell homeostasis. In a murine allogeneic bone marrow transplantation (BMT) model, we previously showed that Treg suppress graft-versus-host-disease (GVHD) without abrogating the beneficial graft-versus-tumor immunological effect. In the current study, we investigate the in vivo trafficking of Treg to better understand how localization may affect their regulatory function. We have developed and characterized a transgenic mouse which constitutively expresses the luciferase gene in all hematologic cells.
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