Abstract
Materials and methods In the present work, we evaluated the in vivo melanomatargeting ability of a nanovector (HFt-MSH-PEG) based on human protein ferritin (HFt), functionalized with both melanoma-targeting melanoma stimulating hormone (a-MSH) and stabilizing poly(ethylene glycol) (PEG) molecules. We used two independent and complementary techniques, such as whole-specimen confocal microscopy and magnetic resonance imaging, to detect the in vivo localization of NP constructs endowed with suitable tracers (i.e., fluorophores or magnetic metals).
Highlights
Nanoparticle (NP)-based materials are very promising agents for enhancing cancer diagnosis and treatment
Materials and methods In the present work, we evaluated the in vivo melanomatargeting ability of a nanovector (HFt-MSH-PEG) based on human protein ferritin (HFt), functionalized with both melanoma-targeting melanoma stimulating hormone (a-MSH) and stabilizing poly(ethylene glycol) (PEG) molecules
We used two independent and complementary techniques, such as whole-specimen confocal microscopy and magnetic resonance imaging, to detect the in vivo localization of NP constructs endowed with suitable tracers
Summary
Nanoparticle (NP)-based materials are very promising agents for enhancing cancer diagnosis and treatment. Once functionalized for selective targeting of tumor expressed molecules, they can deliver drugs and diagnostic molecules inside tumor cells
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