Abstract
Enterococci are major nosocomial pathogens comprising 9% of the over 100,000 primary hospital-acquired bacteremias that occur annually in the United States (4). Despite the significant morbidity and mortality caused by these nosocomial pathogens, little is known of enterococcal traits that promote infection. Recent observations by us indicate that most Enterococcus faecalis and a few E. faecium strains generate substantial extracellular Superoxide (ESO), with invasive isolates having significantly greater production than commensal strains (6). In this study we investigated the role of ESO production in subcutaneous infection using a previously described murine model (5).KeywordsAromatic Amino AcidEnterococcus FaecalisInvasive IsolateSubcutaneous InfectionOklahoma HealthThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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