Abstract
Silver nanoparticles have attracted great interests widely in medicine due to its great characteristics of antibacterial activity. In this research, the antibacterial activity and biocompatibility of a topical gel synthesized from polyvinyl alcohol, chitosan, and silver nanoparticles were studied. Hydrogels with different concentrations of silver nanoparticles (15 ppm, 30 ppm, and 60 ppm) were evaluated to compare their antibacterial activity, nanoparticles’ sizes, and in vivo behaviors. The resulted silver nanoparticles in the hydrogel were characterized by TEM showing the nanoparticles’ sizes less than 22 nm. The in vitro results prove that the antibacterial effects of all of the samples are satisfied. However, the in vivo results demonstrate the significant difference among different hydrogels in wound healing, where hydrogel with 30 ppm shows the best healing rate.
Highlights
In recent decades, nanoparticles (NPs) have been investigated for various biomedical applications and are considered to be the “material of the 21st century” because of their unique designs and property combinations compared with conventional materials [1, 2]
Many benefits of using nanoparticles are proved over other drug delivery systems such as enhancing the solubility of highly hydrophobic drugs, providing sustained and controlled release of encapsulated drugs, and intensifying the stability of therapeutic agents by chemical or physical means and targeted treatments when modified with cell-specific ligands [2]
The results show that this matrix has good physical properties and long-time antibacterial activity [18]
Summary
Nanoparticles (NPs) have been investigated for various biomedical applications and are considered to be the “material of the 21st century” because of their unique designs and property combinations compared with conventional materials [1, 2]. Among all of the nanomaterials, a variety of metallic nanoparticles have been considered as the foremost attention due to their antibacterial application to human health. Antibiotic resistance has always been one of the most significant health threats due to continuous adaptation of microbes to our antibiotic. This problem has risen the attention for metallic drugs that were used to treat infections before the era of antibiotics’ total dominance. The most widely used delegate of metallic NPs is silver nanoparticles (AgNPs) because of their highly effective antibacterial activity both in solution and in components and their extremely large surface area, which provides better contact with
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