Abstract
The goal of this study was to assess the effects of the Hematopoietic Progenitor Cells (HSCs) on full-thickness cutaneous wounds healing in rabbits. Twenty clinically healthy adult New Zealand White rabbits were used in this study; under aseptic technique and general anesthesia full-thickness excisional cutaneous wound; 20 mm x 20 mm were made on the back. The rabbits were randomly partitioned into two. In first group (control group), the wounds were treated with 3ml of saline solution. In second group (Hematopoietic Progenitor Cells- group); wounds were treated with 5x106 (Hematopoietic Progenitor Cells). The result of molecular evaluation along the interval of following-up recorded a significant differences (P<0.05) of the level Fibroblasts Growth Factor (FGF) and Vascular Endothelial Growth Factor (VEGF) recorded at 7, 14 and 35 day post-surgical operation in (Hematopoietic Progenitor Cells- group) compare than control group. These outcomes were parallel with the finding of the clinical and histopathological assessment showed that Hematopoietic Progenitor Cells- group reduces inflammation and promotes epithelialization during 3th weeks with increased vasculature than those in untreated wounds. This study confirms that local implantation of Hematopoietic Progenitor Cells leads to enhance and develop of cutaneous wound healing in rabbit model.
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