Abstract
In several diseased conditions like asthma, allergy, ageing, arthritis, cancer etc., there is a production of reactive nitrogen and oxygen species, as well as our immune system also gets harmed. In order to stop or quench these harmful free radicals, antioxidants, which are the first line of defense, are used. And the immune system can be modulated to work properly by using natural agents like medicinal plants, having antioxidant property. In this context, the present study was undertaken to investigate the immunomodulatory activity and free radical quenching ability of the Boswellia serrata Roxb. (Bs) in murine model. This herb is known to afford protection to human physiological system against diverse stressors. It was tested at three dose levels of 50mg /kg of mice body weight, 100mg /kg of mice body weight, and 150 mg /kg of mice body weight for five consecutive days. Alpha tocopherol (25 mg/ kg, of mice body weight) and Di-methyl Sulphoxide (35mg /kg of mice body weight) were used as the reference standards. The extent of protection against immunosuppression was evaluated after 9 days of respective drug administration, by measuring macrophage phagocytic activity. A statistically significant antioxidant and immunomodulatory activity were shown by the extract of Boswellia serrata as evident by its effect on the activity of non-enzyme antioxidant reduced glutathione (GSH), antioxidant enzyme glutathione peroxidase (GPx), the degree of lipid peroxidation, and increase in the number of peritoneal macrophages.
Highlights
In case of chronic inflammatory conditions, the immune system sometimes go out of the track and harm the host himself
Results expressed in Mean ± standard error of mean (SEM); Replicates: 6 All the results were statistically significant at p
N: Normal; S: Sensitized; NC: Normal Control; SC: Sensitized Control; Boswellia serrata Roxb. (Bs): Boswellia serrata; AT: Alpha Tocopherol quenching of free radicals, it can be said that the intracellular content of reduced glutathione enzyme, and prevention of lipid peroxidation in linoleic acid systems, by the extract of Boswellia serrata indicates that it has a primary role as antioxidants by destroying free radicals
Summary
In case of chronic inflammatory conditions, the immune system sometimes go out of the track and harm the host himself. The immunological responsiveness of an organism can be increased by agents that can modulate the immune system by interfering with its regulatory mechanisms in a process called as immunomodulation [1,2,3]. Chronic inflammatory conditions produce free radicals, which are unstable molecules, as a byproduct. In excessive amounts these free radicals are harmful for healthy tissues [4,5,6]. These radicals can be better scavenged by antioxidation, which a mechanism of stopping or quenching harmful free radicals. For treating an inflammatory condition immunomodulation can go hand in hand with antioxidant activity [7,8,9]
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