Abstract
The combination of nonsense suppression for unnatural amino acid incorporation and heterologous expression in Xenopus oocytes provides a powerful means to probe neuroreceptors and ion channels with chemical precision. Here we describe a range of studies that illustrate the broad potential of this approach. A variety of biophysical probes and reactive moieties can be incorporated. In addition, subtle systematic variations allow detailed, physical organic chemistry studies of the complex proteins of neuroscience. D.A. Dougherty Division of Chemistry & Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA, e-mail: dadougherty@caltech.edu
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