Abstract
Objectives: In vivo perfusion of the entire human colon is an established technique. Although the ascending colon is undoubtedly an important site for salt and water absorption, segmental colonic function in humans has not been adequately investigated. We have, therefore, designed a new in vivo steady state human colonic perfusion technique that allows the measurement of colonic in-flow volumes, and the movement of water and electrolytes in the ascending and distal colon. Results: Eighteen studies were performed on healthy volunteers. The mean total colonic in-flow volume was 2.01 ml/min (s.e. 0.11), which is similar to other studies. The mean water absorption in the ascending and distal colon was 1.24 (s.e. 0.2) and 0.86 (s.e. 0.13) ml/min, respectively
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