Abstract
Kinesin 13 family proteins regulate microtubule dynamics by using the energy of ATP hydrolysis to induce microtubule (MT) depolymerization. They have important roles in regulating MT dynamics during mitosis. Previous work in our lab identified a novel site of interaction of kinesin13 with the MT that leads to the formation of rings wrapping the MT in the presence of AMP-PNP. Several positively charged residues at this site were shown to be required for the formation of the rings but not for depolymerization activity.
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