In vivo rat metabolism and pharmacokinetic studies of ginsenoside Rg 3

Abstract

Metabolism of an anti-tumor active component of Panax ginseng, ginsenoside (20 R)-Rg 3, was studied for better understanding its pharmacokinetics in rat. LC–MS was used to determine Rg 3 and its metabolites in rat plasma, urine and feces samples. An average half-life of 18.5 min was obtained after the ginsenoside was intravenously dosed at 5 mg/kg. However, Rg 3 was not detected in rat plasma collected after oral administration at 100 mg/kg. Only 0.97–1.15% Rg 3 of the dosed amount was determined in feces. Hydrolysis and oxygenated metabolites were detected and identified in feces collected after oral administration by using LC–MS and MS–MS.