Abstract
Herein, initial results are presented as obtained in a hypercholesterol rabbit model with the simultaneous 19F/1H balanced UTE-SSFP technique and using ανβ3-targeted PFOB nanoparticles to establish the feasibility of high sensitivity MR molecular imaging of Gd-free, fluorine-based, clinically-relevant contrast agents.
Highlights
Summary initial results are presented as obtained in a hypercholesterol rabbit model with the simultaneous 19F/1H balanced ultra-short echo time (UTE)-SSFP technique and using aνb3targeted perfluoro-octyl bromide (PFOB) nanoparticles to establish the feasibility of high sensitivity MR molecular imaging of Gd-free, fluorine-based, clinically-relevant contrast agents
We hypothesize that a new technique—simultaneous dualfrequency 19F/1H ultra-short echo time (UTE) balanced steady state free precession (b-SSFP) sequence with 3D radial readout—will allow efficient, sensitive imaging of the complex PFOB signal without the need for Gd and
A UTE b-SSFP sequence with simultaneous 19F/1H excitation and 3D radial readout was acquired at six time points postinjection with the following parameters: FOV=140mm, matrix 1123, isotropic voxel Δx=1.25mm, a=30°, excitation bandwidth exBW=9kHz, pixel bandwidth pBW=900Hz, TR=2.0ms, TE=100μs (FID sampling), total scan time 28 min
Summary
Matthew J Goette1*, Anne H Schmieder, Todd A Williams, John S Allen, Jochen Keupp, Gregory Lanza, Samuel A Wickline, Shelton D Caruthers. Summary initial results are presented as obtained in a hypercholesterol rabbit model with the simultaneous 19F/1H balanced UTE-SSFP technique and using aνb3targeted PFOB nanoparticles to establish the feasibility of high sensitivity MR molecular imaging of Gd-free, fluorine-based, clinically-relevant contrast agents. Background aνb3-integrin targeted nanoparticle (NP) emulsions have been shown to detect and quantify angiogenesis and anti-angiogenic therapy in small animal models of atherosclerosis. While these NP were visualized in high resolution pre- and post-injection 1H-MRI via a Gadolinium (Gd) chelate, we seek to image the perfluoro-octyl bromide (PFOB) core directly via 19F MR. We hypothesize that a new technique—simultaneous dualfrequency 19F/1H ultra-short echo time (UTE) balanced steady state free precession (b-SSFP) sequence with 3D radial readout—will allow efficient, sensitive imaging of the complex PFOB signal without the need for Gd and
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