Abstract
Objectives: Locus coeruleus (LC) pathology in Parkinson's disease (PD) precedes and may be of even greater magnitude than that in the substantia nigra (SN). Novel magnetic resonance imaging (MRI) techniques now provide an opportunity to visualise and quantify LC degeneration in vivo. In this study we used in vivo T1-weighted Fast Low Angle Shot (FLASH) imaging to assess changes in LC volume and MRI contrast with respect to the SN in idiopathic PD and assessed the relationship to motor and non-motor symptoms.
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