Abstract
Continuous monitoring of in vivo pulsatile blood flow and pulse wave velocity (PWV) is important for clinical applications. These parameters are correlated with physiological parameters, such as blood pressure and elasticity of blood vessels. A multimode fiber diffuse speckle contrast analysis (MMF-DSCA) system was developed for fast measurement of in vivo pulsatile blood flow and pulse wave velocity. With MMF and CCD sensor, the diffuse speckle could be captured and processed with higher temporal resolution of 3 ms. We also induced for the first time an MMF-DSCA for evaluation of PWV, which allows estimation of the blood pressure continuously. To validate its performance, both phantom and in vivo experiments were conducted. The results demonstrate that MMF-DSCA could achieve fast pulsatile blood flow measurement with detailed information of the pulse wave profile and velocity. Taking the advantages of being simple and cost-effective, the flexible system can be easily adapted for continuous monitoring of vital biosigns, such as heart rate, pulse wave, and blood pressure.
Highlights
Cardiopulmonary parameters, such as pulse wave velocity (PWV) and heart rate, are crucial for clinical diagnosing and daily healthcare monitoring [1]
Linear approximation of the relation between diastolic blood pressure (DBP) and PWV shows lower level of correlation. These results demonstrated that MMF-diffuse speckle contrast analysis (DSCA) system achieved fast pulsatile blood flow measurement and extraction of the PWV and blood pressure (BP)
We present an MMF-DSCA system for measuring instantaneous blood flow and pulse wave velocity in deep tissue
Summary
Cardiopulmonary parameters, such as pulse wave velocity (PWV) and heart rate, are crucial for clinical diagnosing and daily healthcare monitoring [1]. PWV is the speed of the pulse wave generated by the heart and transfers along the arterials. It is considerably high (5–15 m/s) and carries information of cardiovascular function and vessel viability [2]. PWV in the aorta has been estimated by measuring the delay in the foot of the wave between ascending aorta and femoral artery. Assessment of PWV is important for daily healthcare monitoring, especially for infants and elderly [7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
