Abstract
An emerging clinical modality called proton magnetic resonance spectroscopy (1H-MRS) enables the non-invasive in vivo assessment of tissue metabolism and is demonstrating applications in improving the specificity of MR breast lesion diagnosis and monitoring tumour responsiveness to neoadjuvant chemotherapies. Variations in the concentration of choline-based cellular metabolites, detectable with 1H-MRS, have shown an association with malignant transformation of tissue in in vivo and in vitro studies. 1H-MRS exists as an adjunct to the current routine clinical breast MR examination. This review serves as an introduction to the field of breast 1H-MRS, discusses modern high-field strength and quantitative approaches and technical considerations, and reviews the literature with respect to the application of 1H-MRS for breast cancer.
Highlights
Breast cancer remains a significant cause of morbidity and mortality in women internationally [1]
Proton magnetic resonance spectroscopy (1H-MRS) represents a non-invasive and non-ionising method of characterising a user-selected volume of tissue on the basis of the metabolic content. 1H-MRS has been evaluated as an adjunct modality to breast magnetic resonance imaging (MRI) for increasing the specificity in differentiating malignant from benign tumours, in addition to its potential in monitoring responsiveness to chemotherapy
English language studies investigating single-voxel (SV) or multi-voxel evaluation of the total choline containing resonance using in vivo 1H-MRS assessment of preoperative local or advanced breast cancer in human adult females, with or without additional assessment of benign or normal breast tissues, were sought
Summary
Breast cancer remains a significant cause of morbidity and mortality in women internationally [1]. Proton magnetic resonance spectroscopy (1H-MRS) represents a non-invasive and non-ionising method of characterising a user-selected volume of tissue on the basis of the metabolic (chemical) content. 1H-MRS has been evaluated as an adjunct modality to breast MRI for increasing the specificity in differentiating malignant from benign tumours, in addition to its potential in monitoring responsiveness to chemotherapy. This article aims to review choline related 1H-MRS in breast assessment, and to discuss the qualitative and quantitative approaches to 1H-MRS in breast cancer investigation. Both approaches to the technique will be described, along with a summary of the reported studies
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
