Abstract
A pharmacokinetic model for triazinate uptake in L-1210 cells in mice and W-256 cells in rats was developed to describe the observed concentration profiles with time in these cells following a 36 mg/m2 ip injection. The L-1210 cell permeability to triazinate was found to be ~15 times smaller compared with W-256 cells. Similarly, the partition coefficient for L-1210 cells was calculated to be ~175 times smaller than for W-256 cells. Cell membrane permeability appears to be the key parameter determining drug transport at a short time after injection.
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