Abstract
This study presents the in vivo electrochemical monitoring of pH using boron doped diamond (BDD) microelectrode and silver needles for potential application in medical diagnosis. Accurate calibration curve for pH determination were obtained through in vitro electrochemical measurements. The increase induced in stomach pH by treatment with pantoprazole was used to demonstrate that it is possible to monitor the pH in vivo using the simple and noninvasive system proposed herein. Using the results of the in vivo and in vitro experiments, a quantitative analysis of the increase in stomach pH is also presented. It is proposed that the catheter-free pH monitoring system presented in this study could be potentially employed in any biological environment.
Highlights
In vivo pH monitoring using boron doped diamond microelectrode and silver needles: Application to stomach disorder diagnosis
This study presents the in vivo electrochemical monitoring of pH using boron doped diamond (BDD) microelectrode and silver needles for potential application in medical diagnosis
Proton pump inhibitors (PPIs) were shown to normalize the dysregulated pH in tumor microenvironment and, sensitize cancer cells to anticancer drugs[5,6]. These findings suggest that the use of noninvasive in vivo pH monitoring within tumor tissue provides essential information for improving the efficacy of combination chemotherapy with anticancer drugs and PPI
Summary
In vivo pH monitoring using boron doped diamond microelectrode and silver needles: Application to stomach disorder diagnosis. This study presents the in vivo electrochemical monitoring of pH using boron doped diamond (BDD) microelectrode and silver needles for potential application in medical diagnosis. Proton pump inhibitors (PPIs) were shown to normalize the dysregulated pH in tumor microenvironment and, sensitize cancer cells to anticancer drugs[5,6] These findings suggest that the use of noninvasive in vivo pH monitoring within tumor tissue provides essential information for improving the efficacy of combination chemotherapy with anticancer drugs and PPI. The effects of pantoprazole, a proton pump inhibitor, on the stomach pH are presented to demonstrate that owing to the exceptional characteristics of BDD, the system proposed could be adapted for in vivo pH measurements
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