Abstract
We have developed a method for delivery of biocompatible CaCO3 microcontainers (4.0 ± 0.8 µm) containing Fe3O4 nanoparticles (14 ± 5 nm) into skin in vivo using fractional laser microablation (FLMA) provided by a pulsed Er:YAG laser system. Six laboratory rats have been used for the microcontainer delivery and weekly monitoring implemented using an optical coherence tomography and a standard histological analysis. The use of FLMA allowed for delivery of the microcontainers to the depth about 300 μm and creation of a depot in dermis. On the seventh day we have observed the dissolving of the microcontainers and the release of nanoparticles into dermis.
Highlights
The importance of drug delivery and creation a long-term depot in skin for topically applied compounds has been demonstrated [1,2]
We have developed a method for delivery of biocompatible CaCO3 microcontainers (4.0 ± 0.8 μm) containing Fe3O4 nanoparticles (14 ± 5 nm) into skin in vivo using fractional laser microablation (FLMA) provided by a pulsed Er:YAG laser system
Six laboratory rats have been used for the microcontainer delivery and weekly monitoring implemented using an optical coherence tomography and a standard histological analysis
Summary
The importance of drug delivery and creation a long-term depot in skin for topically applied compounds has been demonstrated [1,2]. It is possible to use micro- and nanoparticles as drug carriers for efficient localized delivery and storage of topically applied substances into skin appendages [3]. Creating artificial channels by means of FLMA promotes deeper and better targeted delivery of particles in tissue. Different containers have been suggested as carriers of drugs and photosensitizers, including calcium phosphate [13] and silica nanoparticles [14]. We are presenting results on delivery of CaCO3 containers filled up by Fe3O4 nanoparticles into the rat skin in vivo using a newly designed FLMA-protocol providing increased particle delivery depth aiming to develop a method of long-term depot formation within the dermis
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