In vivo optical clearing of human light and dark skin (Conference Presentation)

Abstract

In this work, using 930-nm optical coherence tomography (OCT) and reflection spectroscopy in a wide wavelength range from UV to NIR, we investigated and confirmed the concept of the possibility of fast and efficient optical clearing of tissue, in particular human skin in vivo when using various agents and enhancers of skin permeability. The combination of a number of physico-chemical factors enhancing permeability increases the OCT signal several times with more than double the penetration depth. For dark skin and in the UV wavelength range, where absorption is high, optical clearing is not so effective, but everything is equally useful.