Abstract
In order to understand pathogenic mechanism of allergic dermatitis, it is important to find morphological changes of the internal structure of the skin by non-invasive imaging. Optical coherence tomography (OCT) is powerful tool for in vivo tomographic imaging of the internal microstructure in biological tissue. We propose in vivo observation of allergic skin of guinea pigs by OCT. As a result, epidermis thickening became evident as the days passing since Day 7, and the capillary vessel expansion was confirmed since Day 14; the process of inflammation development was successfully observed.
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