Abstract
MR microneurography is a noninvasive technique that provides visualization of the microanatomy of peripheral nerves, otherwise available only with histopathology. The objective of this study was to present a protocol to visualize the microstructure of peripheral nerves in vivo, using a 3T MRI scanner with a clinical set of coils and sequences. The tibial and the common peroneal nerves of healthy volunteers were imaged above the medial malleolus and at the level of the fibular head, respectively. The acquired images provided details about the internal structure of peripheral nerves, with visualization of the fascicles, the interfascicular fat, the epineurium, and the perineurium. MR microneurography can be performed in a clinical setting with acceptable imaging times and can be a potentially powerful tool that complements standard MR neurography.
Highlights
Magnetic resonance imaging (MRI) of peripheral nerves, known as MR neurography, provides visualization of the main peripheral nerve trunks and allows detection of pathologic changes such as edema, loss of fascicular pattern, osteofibrous tunnel narrowing, and tumors [1]
According to the commonly utilized Seddon and Sunderland classifications for peripheral nerve injuries [3, 4], the integrity of the connective tissues such as the epineurium and perineurium is related to clinical outcome [5]
The objective of this study was to present a protocol of MR microneurography using a 3T scanner and a clinical set of coils and sequences, Table 1
Summary
Magnetic resonance imaging (MRI) of peripheral nerves, known as MR neurography, provides visualization of the main peripheral nerve trunks and allows detection of pathologic changes such as edema, loss of fascicular pattern, osteofibrous tunnel narrowing, and tumors [1]. One main issue with standard MR neurography is spatial resolution, the nerve fibers, the fascicles and the connective tissues within the peripheral nerves are not accessible with conventional imaging protocols. According to the commonly utilized Seddon and Sunderland classifications for peripheral nerve injuries [3, 4], the integrity of the connective tissues such as the epineurium and perineurium is related to clinical outcome [5]. Current standard of care utilizes a combination of clinical findings and electrophysiology for diagnosis. A technique that can visualize and evaluate earlier the integrity of the epineurium and the perineurium may potentially improve diagnosis
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
