Abstract
The metabolic distribution via blood from liver of glycerolipids by omega-6 to omega-3 fatty acid (-6 -3) ratio in monogastric animal nutrition is very important. In vivo monitoring technique using jugular-vein-cannulated rats as a nutritional model for monogastric animal can yield important insights into animal nutrition. This study was conducted to determine the effect of different -6 -3 ratios (, , , ) on metabolic distribution of glycerolipids newly synthesized and secreted in the liver of the rats and explore the mechanism involved. Regarding released from oxidation of glycerolipid metabolism, it was the highest (22.5 %) in groups with a -6 -3 ratio of (). The control group showed the highest total glycerolipid level, followed by the , , and groups in order (). When secreted triacylglycerol level of each group was compared with that of the control group, the , , and groups were decreased by 36.3 %, 20.9 %, and 13.3 %, respectively (). Regarding the distribution of phospholipid against total glycerolipid compared to the control group, the , , and groups were 1.38, 1.29, and 1.17 times higher, respectively (). In the comparison of emission against total glycerolipid compared with the control group, the , , and groups were 1.61, 1.52, and 1.29 times higher, respectively (). These results demonstrate that a dietary -6 -3 fatty acid ratio of could significantly decrease harmful lipid levels in the blood by controlling the mechanism of metabolic distribution via blood from triglyceride and phospholipid newly synthesized in the liver of cannulated rat.
Highlights
Humans and other mammals cannot synthesize omega-6 (n6) or omega-3 (n-3) unsaturated fatty acids because they do not have endogenous enzymes necessary to insert a cis double bond at the n-6 or the n-3 position of a fatty acid
The objective of this study was to determine the effect of different n-6 to n-3 fatty acid ratios (71 : 1, 4 : 1, 15 : 1, 30 : 1) on metabolic distribution of glycerolipids newly synthesized and secreted in the liver of the rats as a nutritional research model to monogastric animal and explore the mechanism involved using an in vivo monitoring technique in rats attached with a jugular-vein cannula
Regarding the 14CO2 emission rate by glycerolipid metabolism of rats, the 4 : 1 group had the highest rate while the control group had the lowest rate
Summary
Humans and other mammals cannot synthesize omega-6 (n6) or omega-3 (n-3) unsaturated fatty acids because they do not have endogenous enzymes necessary to insert a cis double bond at the n-6 or the n-3 position of a fatty acid These essential fatty acids have to be supplied from a diet (Gogus and Smith, 2010; Simopoulos, 2016). The Western diet contains high levels of n-6 but low levels of n-3 fatty acids, with an n-6 to n-3 ratio as high as 20 : 1. Decreasing n-6 / n-3 fatty acid ratio in a diet can reduce the risk of critical cardiovascular diseases (Bucher et al, 2002; Simopoulos, 2008).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
