Abstract
Though it has been only a decade since the discovery of Helicobacter pylori, the organism is now known to be associated with three significant human diseases: active chronic gastritis, peptic ulcer disease and gastric adenocarcinoma1–4. Most recently, H. pylori has been incriminated in the aetiology of a fourth gastric disease, malignant lymphoma of mucosa-associated lymphoid tissue of the stomach5. Thus, the study of naturally occurring infections with gastric Helicobacter species in laboratory animals, as well as the use of selected animals experimentally infected with gastric helicobacters, have been increasingly used to dissect the role of this genus of bacteria in eliciting gastroduodenal disease.
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