Abstract
We investigated in vivo labelling of DNA in single organs of female Wistar rats after application of 3H-methionine. In 40 g and 120 g rats the tritium incorporation into DNA was 10 times higher in spleen than in liver, kidney and heart. DNA methylation in newborn rats (6 — 8 g) was more pronounced in each of these organs. We demonstrated a varying degree of tritium incorporation into the different bases of DNA depending on the organs. We claim that only the values for 5-methylcytosine should be used as sole criteria of DNA methylation. Our results indi cate that DNA methylation in vivo is enhanced in those organs, where a more intensive DNA synthesis occurs.
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