Abstract
To report variation of choriocapillaris (CC) flow in widefield in high in myopic subjects compared with an age-matched normal control group using ultra widefield optical coherence tomography angiography (UW-OCTA). This is a Prospective, cross-sectional study. Thirty high myopia subjects and fifty healthy subjects were enrolled. Healthy and high myopia subjects were imaged with the SS-OCTA system (PLEX Elite 9000, Carl Zeiss Meditec Inc., Dublin, CA, USA). For each eye, five 12 × 12-mm OCTA volume scans were acquired. The en face CC images were then exported to imageJ and a semi-automated algorithm was used for subsequent quantitative analysis. The main outcome was a quantitative analysis of the CC. This analysis was performed in three different regions: (i) peripapillary, (ii) macular, and (iii) periphery. In addition, CC variables were further investigated in distinct fields within these three different regions. Thirty myopic eyes (32 subjects; myopic group) and fifty eyes (50 subjects; control group) without elevated myopia were included in the analysis. Mean ± SD age was 26.9 ± 2.9 years [median: 27 years; range: 20.0–40.0 years]. Mean ± SD axial length was 26.6 ± 0.6 mm [median: 26.2 mm; range: 26.1 to 28.0 mm]. Mean ± SD axial length was 26.6 ± 0.6 mm [median: 26.2 mm; range: 26.1 to 28.0 mm] in the myopic group and 23.9 ± 1.1 mm [median: 23.9 mm; range: 21.8 to 25.9 mm] in the control group. The total signal void area was significantly greater in myopic eyes compared with control group. The peripapillary region exhibited the greatest total signal void area (p < 0.0001 vs macular region, p < 0.0001 vs peripheral region). Within the macular region, the foveal area exhibited a greater total signal void area in comparison with both the parafoveal area (p < 0.0001) and the perifoveal area (p < 0.0001). In conclusion we report quantitative mapping of the choriocapillaris in myopic eyes compared with an age-matched normal control group. The CC perfusion appears to have a wide topographical variation.
Highlights
The choriocapillaris (CC) represents an approximately 10-μm-thin layer of capillaries limited to the innermost part of the choroid, located between Bruch’s membrane and the medium-sized choroidal vessels[1]
In high myopia the increased axial length may lead to development of several retinal complications, including posterior staphyloma, retinoschisis, lacquer crack (LC) formation, chorioretinal atrophy, and myopic neovascularization[9,10]
Thirty eyes of 30 patients (20 female, 10 male) with high myopia were included in this study
Summary
The choriocapillaris (CC) represents an approximately 10-μm-thin layer of capillaries limited to the innermost part of the choroid, located between Bruch’s membrane and the medium-sized choroidal vessels[1]. A higher speed system allowed the acquisition of a larger field of view, ensuring a wider investigation of the retinal and choroidal vessels This kind of technology grants to image from the macula to the far www.nature.com/scientificreports retinal periphery and is termed ultra-widefield (UWF) OCTA imaging. Previous studies using different imaging modalities have investigated choroidal blood flow changes showing a decreased total number of flow voids CC associated with high myopia[5,11,12]. These studies have improved the evaluation on the CC function and characteristics, an important limitation was that this assessment was limited to the macular region. These measurements were determined in different retinal regions in order to provide a topographical analysis of the CC perfusion
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