Abstract
Purpose: Musculoskeletal tissues not only bear joint loads, but actively adapt their structure and composition to the mechanical environment. However, our understanding of the mechanisms of this functional adaptation is limited, particularly in complex systems such as synovial joints. For example, adaptive changes in articular cartilage and underlying subchondral bone are both key contributors to osteoarthritis (OA) pathogenesis. Using well-controlled mechanical loading, we have been studying the in vivo response of joint tissues to mechanical stimuli.
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