Abstract
Cytotoxic and genotoxic examinations were performed of the effect of levamisole hydrochloride (2.2 mg/kg bm, 4.4 mg/kg bm, LD50-25% mg/kg bm and LD50-75% mg/kg bm) on bone marrow cells of mice of the BALB/c strain. The effect of levamisole hydrochloride on kinetics of the cellular cycle and the appearance of structural and numerical changes in chromosomes of bone marrow cells were followed. The therapeutic dose of levamisole of 2.2 mg/kg bm showed the ability to increase the mitotic activity of the observed cells, thus confirming knowledge of the immunostimulative effect of this dose of the medicine under in vivo conditions. The other tested doses of levamisole in this experiment, observed in comparison with the control group, had an opposite effect, i.e. they caused a reduction in the mitotic activity of bone marrow cells. All the examined doses in vivo showed the ability of inducing numeric (aneuloid and polyploid) and structural (lesions, breaks and insertions) chromosomal aberrations. On this basis, it can be concluded that the examined doses have a genotoxic effect.
Highlights
Obavljena su citotoksi~na i genotoksi~na ispitivanja levamizol hidrohlorida (2.2 mg/kg, t.m., 4,4 mg/kg t.m, LD50-25% mg/kg t.m. i LD5075% mg/kg t.m) na }elijama kostne sri mi{a BALB/c soja.
Kuli} i sar: In vivo ispitivanje klastogenog efekta Levamizol hydrochlorida na }elijama kostne sri mi{eva BALB/c soja cima klase Nematoda.
Rezultati ispitivanja uticaja odgovaraju}ih doza levamizol hidrohlorida na vrednosti mitotskog indeksa, kao mere proliferativne aktivnosti }elija kostne sri mi{a prikazani su u tabeli 1.
Summary
Obavljena su citotoksi~na i genotoksi~na ispitivanja levamizol hidrohlorida (2.2 mg/kg, t.m., 4,4 mg/kg t.m, LD50-25% mg/kg t.m. i LD5075% mg/kg t.m) na }elijama kostne sri mi{a BALB/c soja. Kuli} i sar: In vivo ispitivanje klastogenog efekta Levamizol hydrochlorida na }elijama kostne sri mi{eva BALB/c soja cima klase Nematoda. Rezultati ispitivanja uticaja odgovaraju}ih doza levamizol hidrohlorida na vrednosti mitotskog indeksa, kao mere proliferativne aktivnosti }elija kostne sri mi{a prikazani su u tabeli 1.
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