In vivo indicator dilution kinetics of PAH transport in dog kidney

Abstract

Pages F255–F265: M. Silverman, C. Whiteside, C. J. Lumsden, and H. Steinhart. “In vivo indicator dilution kinetics of PAH transport in dog kidney.” Two important early studies of PAH transport in the kidney were carried out using the pulse-injection, multiple indicator dilution technique (MID). These references were overlooked in our citations. Page F261: the text should read “Probenecid is a known inhibitor of organic ion transport. Chinard et al. (35) noted that probenecid doses of 25 mg/kg body wt, when administered to dogs 20–30 min prior to an MID run, resulted in renal vein outflow curves for hippurate nearly identical to those of simultaneously injected creatinine. Figure 5 illustrates our control and experimental runs using probenecid as an inhibitor of [3H]PAH transport .” Page F263: the text should read “As Chinard showed in the earliest renal MID work on PAH known to us (36), the MID technique as used in this study has the advantage of allowing one to look at events occurring simultaneously at opposing nephron surfaces in the anesthetized dog, under nearly normal physiological conditions (see also Ref. 27).”