Abstract
As per Ayurveda symptoms of Rheumatoid arthritis resembles with Amavata disease. Action of Hinguleshwara rasa on Amavata is mentioned in the text of Rasatarangini in Ayurveda. In this study investigation was made to find out preventive & curative changes occurred in rat paw of Freuds Complete Adjuvant induced RA model. Indomethacin was kept as standard control and Hinguleshwar rasa as a treatment. After induction of arthritis with FCA on day 14, animals were treated up to 28th day of the study with indomethacin and Hinguleshwar rasa. After completion of 28 days of daily single oral dose administration of Hinguleshwar rasa and Indomethacin, animals were sacrificed. Ankle joints were severed and processed for histological studies. It was observed that the joints of Hinguleshwar rasa treated animals showed recovery towards normal histological architecture whereas all other joint samples of bones of rats were showing focal and minimal pathological changes, focal and minimal congestion of blood vascular tissue. Similar normal Histo-architecture was found in Indomethacin treated animals. However it was observed that, Hinguleshwar rasa showed better restoration of joint Histopathological changes occurred due to FCA damage. Hence the efficacy of Hinguleshwar rasa on Amavat (Rheumatoid arthritis) was better than Indomethacin treatment.
Highlights
Amavata disease is mentioned in the text Madhav nidan in Ayurveda
It was observed that the joints of Hinguleshwar rasa treated animals showed recovery towards normal histological architecture whereas all other joint samples of bones of rats were showing focal and minimal pathological changes, focal and minimal congestion of blood vascular tissue
Studies shows that people who receive early treatment for Rheumatoid arthritis (RA) feel better and more often likely to lead an active life at sooner They are less likely to have the type of joint damage that leads to joint replacement.[2]. In this study investigation was made to find out the kind of preventive & curative changes occur after oral administration of Hinguleshwar rasa and Indomethacin to FCA induced RA in paw of rat model
Summary
Amavata disease is mentioned in the text Madhav nidan in Ayurveda. The symptoms of Amavata like painful swelling in the joints of hands & feet, cervical region, girdles, stiffness etc. RA causes pain and swelling in the wrist and small joints of the hand and feet. Treatment of RA may stop joint pain and swelling as well as prevents joint damage. Studies shows that people who receive early treatment for RA feel better and more often likely to lead an active life at sooner They are less likely to have the type of joint damage that leads to joint replacement.[2] In this study investigation was made to find out the kind of preventive & curative changes occur after oral administration of Hinguleshwar rasa and Indomethacin to FCA induced RA in paw of rat model
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