IN VIVO HEPATOPROTECTIVE ACTIVITY OF CASSIA AURICULATA POLYMER NANOSPHERES CONTAINING SILYMARIN

Abstract

ABSTRACTObjective: Hepatoprotective activity of herbal drugs has an importance in the treatment of hepatic disorders, but pharmaceutically engineeredproducts are not evolved properly to cure the liver disorders properly based on the demand and also route, target the appropriate site of action.Methods: In our present work, we have been developed a new formulation that possesses a unique nature and site specificity for targeting the diseasestate. Here, we examined hepatoprotective activity of Cassia auriculata polymer nanospheres containing silymarin against carbon tetrachlorideinducedhepatotoxicityinratsusingat50mg/kgand100mg/kgbodyweightdoselevels,andwehavebeen observedthat enzymeactivitiesof serumglutamateoxaloacetatetransaminase,serum glutamatepyruvatetransaminase,alkalinephosphate,totalprotein,albumin, globulin,totalcholesterol,high-densitylipoprotein(HDL), glutathione(GSH), and totalbilirubin wereanalyzed.Results: C. auriculata polymer nanospheres and silymarin produced significant (p<0.001) hepatoprotective effect by decreasing the activity of serumenzymes, bilirubin, total cholesterol, and increased levels of HDL, total protein, albumin, globulin, and tissue GSH.Conclusion: From these results, it was concluded that of C. auriculata polymer nanospheres would protect the liver cells from carbon tetrachloridefrom liver diseases.Keywords: Hepatoprotective activity, Silymarin, Cassia auriculata, Nanospheres.