Abstract
Objective The objective of this study was to evaluate the hemostatic activity of the sap from Jatropha mollissima (Pohl) Baill. in rats. Materials and Methods Twenty-four Wistar rats were randomized into four groups ( n = 6): the JM25 and JM40 groups were treated with ethanolic extract from the sap of J. mollissima , in a concentration of 25 and 40 mg·mL 1 , respectively; the MO group was treated with Monsel’s solution and the control group SC with a 0.9% sodium chloride solution. Statistical Analysis Data were submitted to the Kurskal–Wallis’ test, followed by Dunn’s post hoc ( p < 0.05). Results There was a significant reduction in the bleeding time of the group from the JM25 extract ( p = 0.001) when compared with MO and SC. There were no statistically significant differences between groups JM25 and JM40 ( p > 0.05). The JM25 group did not present rebleeding, a result significantly different from the MO group ( p = 0.001). Monsel’s solution showed significant bleeding, six times greater than the control group SC. Conclusion The J. mollissima extract, in the concentration of 25 mg·mL 1 , showed the highest hemostatic efficiency and was found to be a promising biomaterial for the elaboration of a hemostatic product.
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