Abstract
In Vivo Genotoxicity of Gold Nanorods in Mouse Bone Marrow Compared with Cyclophosphamide
Highlights
Metallic nanoparticles (NPs) applications have gained much attention in different aspects of biomedicine, owing to their unique size-dependent properties [1]
Paino et al [6] reported that a single short-term treatment of hepatocellular carcinoma cells (HepG2) and peripheral blood mononuclear cells (PBMC) with different concentrations of GNPscitrate or gold NPs (GNPs)-polyamidoamine dendrimers showed a genotoxic effect even with low concentrations of GNPs, they observed that the DNA damage index was less for PBMC comparing to HepG2 upon exposure to GNPs, a finding that indicated cell specificity
After 21 days from Gold nanorods (GNRs) treatment (180 μg kg b. wt./week, for three weeks), bone marrow cells (BMCs) were collected from GNRs, CP- and control groups to assess chromosome aberrations, mitotic activity, sister chromatic exchanges and replicative index, besides measure the potential of GNRs to induce DNA damage using comet and micronucleus tests
Summary
Metallic nanoparticles (NPs) applications have gained much attention in different aspects of biomedicine, owing to their unique size-dependent properties [1]. Paino et al [6] reported that a single short-term treatment of hepatocellular carcinoma cells (HepG2) and peripheral blood mononuclear cells (PBMC) with different concentrations of GNPscitrate or GNPs-polyamidoamine dendrimers showed a genotoxic effect even with low concentrations of GNPs, they observed that the DNA damage index was less for PBMC comparing to HepG2 upon exposure to GNPs, a finding that indicated cell specificity According to these studies the observed DNA damage is caused either as a result of oxidative stress or thought the direct interaction of GNPs with DNA. It is important to point out that all previous reports focused on investigating the GNPs genotoxicity after a short-term treatment period (few to 72 h), using a single administration dose and mostly applied on culture cells Another lack in these studies was their relay on a single genotoxicity analysis (comet assay or chromosomal aberration), which is not enough to cover all forms of DNA damage nor provides an overall conclusion. Our results may direct scientists to know the best strategies to use GNRs in biomedical approaches
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