Abstract
To determine whether degradation could influence the in vivo elimination pattern of poly(β-malic acid) in mice, radioactive urinary excretion and 14CO2 expiration were studied after intravenous injection of 14C-radiolabeled poly(β-malic acid) and of its precursor, 14C-malate. The precursor administration led to rapid 14CO2 exhalation, and only negligible urinary elimination. The reverse was observed for the polymer. It was concluded that: (i) the in vivo degradation of poly(β-malic acid) chains, if any during the 24-h period of the study, did not release detectable malate molecules, (ii) the large urinary excretion of poly(β-malic acid) was due to the molar masses being less than the renal filtration threshold, (iii) the degradation of the poly(β-malic acid) chains in blood was slow enough to allow the fraction with higher molar masses to enter the interstitial space of the tissues, and possibly cells.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
