In Vivo evaluation of wound healing efficacy of κ -Carrageenan blended polyvinyl pyrrolidinone films for wound dressing applications

Abstract

The requisite for novel potential dressings has emerged as a consequence of the incidences of injuries caused due to second intention and expensive treatment costs for the management of them. New generation dressings are capable to accelerate proliferation of cells and regeneration of tissue despite of the protective role to the wounds. Moreover, patient compliance persists as an integral factor with regard to the fact that they create no damage to the newly regenerated tissue on removal of the same. In the current study, we developed a κ- carrageenan film dressing, which is capable to accelerate tissue repair and aids its removal by external stimulus without disturbing the regenerated tissue. The dressing is capable to absorb excessexudate from the wound by maintaining hydrationto wound bed. The medical dressing was evaluated in male Wistar rats by generating a pocket wound. The dressings were implanted in incised pocket wound for 16 days. Histological analyses demonstrated that the dressing inserted on the injured area have showed minimal level of inflammatory events and generated denser connective tissue on comparison to wounds devoid of dressings. The injured site sheltered with the dressing demonstrated re-epithelization and angiogenesis to promote wound closure.