Abstract
Immunology is a branc h of biomedical science that involves all aspects of the immune system that recognize pathogens and initiate defense response that involve induction, expression, amplification or inhibition of phase of the immune response . Plant based medicines have potent ial immunomodulatory activity that can justify their use in past . Ferulic acid ( FA ) is a polyphenol abundant in several plants, possesses activity, such as antioxidant, antimicrobial, anti - inflammatory, anti - thrombosis, anti - cancer and also used in age - rel ated diseases such as neurodegenerative disorders, cardiovascular diseases and diabetes . The study was proposed to determine immunomodulatory effects of FA . Assessment of immunomodulatory activity of FA was done by carbon clearance test, delayed type hyper sensitivity ( DTH ) reaction, neutrophils adhesion test, e ffect on serum immunoglobulins and cyclophosphamide induced neutropenia . FA at doses 200 mg / kg p roduced significant increase in phagocytic index ( P<0 . 01 ) which indicated stimulation of reticuloendothe lial system, neutrophil count ( P<0 . 05 ) in nylon fibers which causes the stimulation of neutrophils towards the site of inflammation, the serum immunoglobulin levels ( P<0 . 05 ) shows direct measure of T and B cell activity, TLC count ( P<0 . 05 ) and prevent n eutropenia through activation of macrophages and increase in DTH response ( P<0 . 05 ) which indicate stimulatory effect on lymphocyte . On the basis of present investigation, it can be concluded that FA has potential to stimulate overall immune system in the experimental animals .
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