In vivo estimation of normal left ventricular stiffness and contractility based on routine cine MR acquisition

Abstract

Post-myocardial infarction remodeling process is known to alter the mechanical properties of the heart. Biomechanical parameters, such as tissue stiffness and contractility, would be useful for clinicians to better assess the severity of the diseased heart. However, these parameters are difficult to obtain in the current clinical practice. In this paper, we estimated subject-specific in vivo myocardial stiffness and contractility from 21 healthy volunteers, based on left ventricle models constructed from data acquired from routine cardiac MR acquisition only. The subject-specific biomechanical parameters were quantified using an inverse finite-element modelling approach. The personalized models were evaluated against relevant clinical metrics extracted from the MR data, such as circumferential strain, wall thickness and fractional thickening. We obtained the ranges of healthy biomechanical indices of 1.60 ± 0.22 kPa for left ventricular stiffness and 95.13 ± 14.56 kPa for left ventricular contractility. These reference normal values can be used for future model-based investigation on the stiffness and contractility of ischemic myocardium.