Abstract
Rats were depleted of body Fe stores by providing their mothers with Fe-free environments. At weaning, the Fe-depleted pups were supplemented with Fe which resulted in a dose-dependent increase in hematocrit, liver weight, and body weight. The supplemental Fe, as 57Fe and 59Fe, was incorporated into the hepatic mixed function oxidase enzyme system to a maximum enrichment of 79%. This was accomplished with a maximum excretion of 20.5% of the ingested Fe dose. Iron depletion and resupplementation did not alter the concentration of cytochromes b 5 and P-450, drug metabolizing activity, nor the ability of the enzyme system to respond to phenobarbital inductions.
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