Abstract
Electron paramagnetic resonance imaging, EPRI, is an emerging in vivo imaging modality that holds a unique promise of quantitatively mapping tissue oxygen distribution noninvasively. Unlike magnetic resonance imaging (MRI), EPRI requires the use of nontoxic biologically compatible spin probes. Many tumors are characterized by a hypoxic core that is highly resistant to radiation and chemotherapeutic treatment. EPRI enables fast noninvasive assessment of tumor hypoxia, re-oxygenation, and tissue redox status. The two main approaches to EPRI are continuous wave, CW electron paramagnetic resonance (EPR) spectroscopy, and time-domain EPR spectroscopy, FT-EPR. The present article describes the current state of the art of radiofrequency CW and time-domain EPR imaging.
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