Abstract

B-cell maturation antigen (BCMA) targeted chimeric antigen receptor-T (CAR-T) cells generate short-lived responses in multiple myeloma (MM) with high risk of cytokine release syndrome and neurotoxicity. Expressing CAR proteins on alternative cell types could lead to a less toxic cure. Invariant natural killer T-cells (iNKTs) express a monomorphic T cell receptor that recognizes glycolipids displayed by the MHC-like molecule CD1d. iNKTs do not cause graft versus host disease (GvHD), making them a useful alternative cell type for an allogeneic,

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