Abstract
The in vivo antiesterase activity of three carbamate insecticides was examined by an abbreviated manometric assay. A comparison of this method with a potentiometric esterase assay indicated the feasibility of the abbreviated manometric assay for routine determination of reversible esterase inhibitors. The intensity of the cholinergic effects produced after carbamate intoxication correlated with the degree of cholinesterase inhibition. Inhibition and recovery of liver aliphatic esterase activity did not correlate with signs of poisoning. A comparison was made of the response of rat and mouse liver esterases to in vivo carbamate poisoning.
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