Abstract
The effects of 24R, 25-dihydroxyvitamin D3 (24, 25 (OH)2 D3) on alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT) and acid phosphatase (ACP) activities were investigated on renal cortex of hypophysectomized (Hx) rats. ALP activity was increased by +27, +56 and +60% as compared to controls respectively 3, 6 and 12 h after intraperitoneal administration of the secosteroid (10 pmoles/100 g body weight). Stimulations of GGT activity began only after 6 h (+30%) and 12 h (+ 46%). ACP activity was not modified. In vivo, the two enzymatic inductions in kidneys of Hx rats were higher and longer than those obtained in vitro.
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Schedule a callMore From: Archives internationales de physiologie, de biochimie et de biophysique
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