Abstract

Neural communication between rodent ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC) supports cognitive functions such as spatial working memory. Impaired vHPC-mPFC communication underlies cognitive deficits in rodent models relevant to schizophrenia. Neural activity in vHPC-mPFC projections and mPFC somatostatin-positive (SST+) interneurons are essential for normal vHPC-mPFC communication and spatial working memory. Whether and how these neural substrates interact to support vHPC-mPFC communication is unclear.

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