Abstract
Eighteen healthy male Swiss albino mice of specific weight (25–30g) were randomly divided into three groups of six animals each and given specific diets for a period 28 days. Group A was given normal synthetic diet (NSD) and milk; Group B: NSD and Withania somnifera (WS) extract (0.3%) and Group C: NSD supplemented with milk and WS extract (0.3%). The phagocytic activity of peritoneal macrophages and Immunoglobulin G (lgG) level in mice serum increased significantly in comparison to control group in WS-supplemented groups. The lymphocyte proliferation index did not alter significantly (P < 0.05) in supplemented groups after a period of 28 days. Group B and C showed significantly higher reduced glutathione level and significantly lowered (P < 0.05), carbonyl protein and thiobarbituric acid reactive substances in liver and red blood cells lysates as compared to control. This finding indicated that aqueous extract of WS is able to enhance immunomodulatory and antioxidative properties of milk.
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