Abstract
<p><strong>Ethnopharmacological relevance:</strong> The fruits of <em>Buchanania lanzan</em> are used traditionally in the treatment of skin afflictions, sores, ulcers, inflammation and as diuretic (1,21,35,42). The aim of the study was to investigate the antiulcer and diuretic activity of the crude ethanolic and pet. ether extract from the fruits of <em>Buchanania lanzan</em>.</p><p><strong>Materials and methods:</strong> The antiulcer activity of the crude extracts was evaluated in ethanol and pylorus ligation induced model for gastric lesions in Wister albino rats (2,8,12,19). Parameters such as gastric volume, pH and acidity were determined in the pylorus ligation model. Furthermore the diuretic activity was evaluated in comparison of Standard drug i.e. Furosemide.</p><p><strong>Results: </strong>The acute toxicity studies revealed that LD50&gt; 2000mg/kg for the extract.<strong> </strong>The extract caused a significant (p&lt;0.05) dose-dependent inhibition of ulcer in the ethanol and pylorus ligation induced ulcer models at the dose of 250mg/kg, respectively. And the diuretic activity of extract also found significant (p&lt;0.01) dose dependent increase in urine volume. Both ethanol and aqueous extracts have showed a significant dose-dependent increase in the excretion of electrolytes when compared to the control group.</p><p><strong>Conclusion:</strong> Our data provide a rational base for the folkloric use of <em>Buchanania lanzan</em> in the treatment of ulcers and as diuretic.</p>
Highlights
Buchanania lanzan is claimed to have diuretic and antiulcer activity in indigenous system of medicine [3,6,9]
A survey of the literature revealed the absence of any systematic study on diuretic and antiulcer activity of the plant [13,15,19,25]
A study has been taken up to verify the claims made in the indigenous system of medicine
Summary
Buchanania lanzan is claimed to have diuretic and antiulcer activity in indigenous system of medicine [3,6,9]. Buchanania lanzan is a tree which produces the seeds known as charoli. These seeds are used as a cooking spice primarily in India [7,16,24,27,33]. Charoli are tiny almond-flavoured dried seeds of a bush called Buchanania lanzan, which is cultivated across India, primarily in the northwest [33,38,49]. The charoli seed is lentil-sized, is slightly flattened and has an almondlike flavour (). Though they can be eaten and used raw they are often toasted or roasted before use, as this intensifies the flavour.They are commonly used in sweets in India. Charoli seeds are used in the Ayurveda and Unani system of medicine [33,35,42]
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