Abstract
A method for noninvasive simultaneously detecting hemoglobin oxygen saturation (SO<sub>2</sub>) and carboxyhemoglobin saturation (SCO) in subcutaneous microvasculature with multi-wavelength photoacoustic microscopy (PAM) is presented. <i>In vitro</i> blood samples mixed with different concentration of carboxyhemoglobin were used to testify the feasibility and accuracy of the PAM. Moreover, fixed-point detection of SO<sub>2</sub> and SCO of the vessel in mouse ear were obtained. And the changes of SO<sub>2</sub> and SCO from normoxia to carbon monoxia hypoxia were dynamically recorded <i>in vivo</i>. Experimental results demonstrate that the PAM has the capability to detect SO<sub>2</sub> and SCO, which has potential application in clinic.
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