Abstract
Thioglycolate injected i.v. in dosages of 50 mg/kg, significantly depressed hepatic succinoxidase in immature rats of either sex and adult males whereas, about a five-fold excess was required to elicit a significant response in adult females. Ovariectomy increased and estradiol pretreatment, decreased the sensitivity to thioglycolate. Of a number of sulfur compounds screened on hepatic succinoxidase in males, only 2-mercaptoethanol shared this action with BAL and thioglycolate. The latter two agents were without effect on cytochrome oxidase and diaphorase but both depressed NADH cytochrome c reductase. It is suggested that the mechanism of succinoxidase inhibition involves a combination with Slater's factor, thereby causing a disruption in the normal flow of electrons.
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