Abstract
The cytotoxicity of misonidazole (miso) in vivo in unclamped tumors at hyperthermic temperatures, and in clamped tumors at hypothermic, euthermic, and hyperthermic temperatures has been examined. No cytotoxicity, measured as increased tumor control, was observed in unclamped tumors heated 30 min after systemic miso administration. This may reflect the short serum half-time of miso in the mouse and a small hypoxic fraction in this tumor system. There was, however, significant miso cytotoxicity in clamped tumors at euthermic and hyperthermic temperatures when the clamp was applied 30 min after systemic miso. The degree of cytotoxicity observed was dependent upon the temperature of incubation, the length of clamping, and the dose of miso.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
