Abstract
Acrylamide significantly increased the number of cells with chromosome aberrations in BALB/c and C57B1/6, but not in CBA mice. No difference was found between the BALB/c and C57B1/6 strains in the clastogenic effect of acrylamide. Within the studied concentration range acrylonitrile exerted no genotoxic effects. Verapamil significantly potentiated the clastogenic effect of acrylamide in BALB/c mice, while in C57B1/6 mice potentiation was observed only after the repeated intragastric administration of verapamil in a dose of 2.5 mg/kg. Acrylonitrile in combination with verapamil also produced a slight clastogenic effect after single and repeated administrations. Thein vivo comutagenic activity of verapamil depended on the dose, administration route and schedule, and genotype of experimental animals.
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